Detection of Lgr5/GPR49 antibody in HEK293 Human Cell Line Transfected with Leucine‑rich repeat G‑protein‑coupled receptor 5 (Lgr5), also called GPR49,
2013-03-07
MiR-142-3p functions as a tumor suppressor by targeting CD133, ABCG2, and Lgr5 in colon cancer cells LGR5 human Fusion Protein 6*His from Proteintech. Produced in E.coli-derived, PET28a, with high quality purity. Cat.No. Ag29025 Expression of LGR5 (FEX, GPR49, GPR67, HG38) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers.
Our product picks are editor-tested, expert-approved. We may earn a commission thr Proteins perform nearly every function carried out by the body on a cellular level. All proteins are built from the same 20 amino acids, and the function o Proteins perform nearly every function carried out by the body on a cellular level. From chicken breast to tofu , WH have created your guide to lean protein. We earn a commission for products purchased through some links in this article. The foundation of your healthy eating We all know lean protein is important, right? Es Americans are trying to get more protein in their diets.
Lgr5 (leucine-rich repeat G-protein coupled receptor 5), also called GPR49, is a seven-transmembrane glycoprotein receptor in the Lgr family of cell surface receptors (1, 2). While this family includes receptors for hormones such as LH, FSH, TSH, and HCG, the subfamily comprising Lgr4, Lgr5, and Lgr6 are G-protein independent mediators of the potentiating effect of R-Spondins on Wnt signaling
If you continue, we'll assume that you are happy to receive all cookies. 2020-03-16 · 606667 - leucine-rich repeat-containing g protein-coupled receptor 5; lgr5 - g protein-coupled receptor 49; gpr49 - lgr5 LGR5, also named as GPR49, GPR67 and HG38, belongs to the G-protein coupled receptor 1 family. It is an orphan receptor. LGR5 is a stem cell marker of the intestinal epithelium and the hair follicule.
12 Jul 2011 LGR5, an orphan receptor of the G protein-coupled receptor (GPCR) superfamily, is specifically expressed in stem cells of the intestinal crypt
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Not determined. Gene Symbol, LGR5. Protein Length, Partial (see sequence information for more details). Product Type, Recombinant Protein. Cross Reactivity
In the intestine, the orphan G-protein coupled receptor LGR5 marks crypt base columnar cells that can differentiate into all cell lineages of the intestinal
Adenoma formation was investigated in ApcMin/+ mice, stem cells were counted in mice with the Lgr5–enhanced green fluorescent protein knock-in allele,
Wnt-dependent, Lgr5-expressing stem/progenitor cells are essential for the development of glandular epithelia in Receptors, G-Protein-Coupled - metabolism. The Lgr5/R-spondin complex acts by neutralizing Rnf43 and Znrf3, two transmembrane E3 ligases that remove Receptors, G-Protein-Coupled - metabolism.
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UniProtKB/Swiss-Prot: LGR5_HUMAN, O75473 Recombinant Human Lgr5/GPR49 Fc Chimera Protein, CF. 2017-09-08 · LGR5 ablation in colon cancer cells and crypt stem cells resulted in loss of cortical F-actin, reduced cell-cell adhesion, and disrupted localization of adhesion-associated proteins. No evidence of LGR5 coupling to any of the four major subtypes of heterotrimeric G proteins was found. LGR5 (HGNC Symbol) Synonyms. FEX, GPR49, GPR67, HG38: Description. Leucine-rich repeat containing G protein-coupled receptor 5 (HGNC Symbol) Entrez gene summary.
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In a cell, proteins are made in the cell's ribosomes.
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Lgr5 is a G‐protein‐coupled receptor. Its ligands have recently been identified as R‐spondins, a group of secreted proteins (Carmon et al., 2011; de Lau et al., 2011). Binding of R‐spondins to Lgr5 triggers the interaction of Lgr5 with Wnt receptors to modulate the Wnt/β‐catenin signaling pathway (Carmon et al., 2012).
Among its related pathways are Signaling by GPCR and mTOR signaling pathway (KEGG). Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) is an orphan GPCR associated with cancer stem cells in intestinal cancers (Barker et al., 2009). It is overexpressed in gastrointestinal tumors and may contribute to tumorigenesis (Tanese et al., 2008). Overall reliability score for the subcellular location (s) of the protein (s) in human cells, and summary of the antibodies used for immunostainings. Read more. Reliability scorei. Overall gene reliability score for the subcellular location (s) of the encoded protein … One member of this class is the leucine‐rich repeat‐containing G‐protein‐coupled receptor 5 (LGR5), a stem cell marker in intestinal crypts, and mammary glands.